Genetics — Adithya Kumar
Predispositions and actionable gene variants from 23andMe.
Your Genetic Traits
Fitness
Muscle fiber type / athletic performance
ACTN3 RR (CC): two functional alpha-actinin-3 copies. Strong fast-twitch and power/sprint adaptation. Responds well to resistance training and explosive exercise.
Prioritise strength and power training. Recovery is fast — high-intensity sessions respond well.
rs1815739 · CC
Lifestyle
Alcohol / aldehyde metabolism
Normal ALDH2 function (GG). Aldehyde cleared efficiently after alcohol. No flush reaction. Standard alcohol guidance applies.
Standard alcohol guidance applies.
rs671 · GG
Caffeine metabolism
Fast caffeine metaboliser (AA). Caffeine cleared 1.5-3x faster than slow metabolisers. Low cardiovascular risk from moderate coffee intake. Ergogenic window is shorter.
Time caffeine 30–60 min before performance. Limited cardiovascular risk at moderate doses.
rs762551 · AA
Cardiovascular
Alzheimer risk / cardiovascular lipids
APOE e3/e3: average population risk for late-onset Alzheimer disease and cardiovascular disease. No elevated LDL elevation from epsilon-4 allele.
Standard heart-health practices apply.
rs429358 · e3/e3
Neurology
Dopamine metabolism / stress response
COMT Val/Met (AG): intermediate dopamine clearance. Balanced stress response and working memory. More sensitive to stimulants under high stress than Val/Val. Shares this variant with Arya.
Standard cognitive-health practices. No specific intervention.
rs4680 · AG
Nutrition
Appetite / weight regulation
One FTO risk allele (AT): ~1.2x higher BMI tendency vs TT. Appetite satiety signals mildly blunted. High-protein diet and resistance training strongly attenuate this effect. Shares with Arya.
Protein-dominant diet + resistance training strongly attenuates FTO effect. Track energy intake.
rs9939609 · AT
Folate metabolism / methylation
Heterozygous C677T: ~35% reduced MTHFR enzyme activity. Methylfolate preferred over folic acid. Slightly elevated homocysteine risk under low-B12 conditions. Linked to ADHD and mood sensitivity in some cohorts.
Prefer methylfolate (5-MTHF) over folic acid. Check homocysteine annually.
rs1801133 · CT
Vitamin D receptor efficiency
VDR FokI Ff (CT): intermediate receptor efficiency. Target 25-OH-D >= 50 ng/mL. 2,000-3,000 IU D3 daily + K2 is reasonable. Shares with Arya.
Target 25-OH-D ≥ 50 ng/mL. 2,000–3,000 IU D3 daily + K2 is reasonable.
rs2228570 · CT
Family Inheritance
Key genes compared across all family members. Shared risk genes may suggest coordinated screening or lifestyle changes.
Shared Family Risk
APOE, FTO — elevated or high risk seen across 2+ family members. Consider coordinated screening or dietary changes.
| Gene | A Arya | K Kumar | A Adithyaself | P Priyamother |
|---|---|---|---|---|
| MTHFR | CC low | CT moderate | CT elevated | CC low |
| APOE | e3/e3 elevated | e3/e3 elevated | e3/e3 elevated | e3/e3 elevated |
| LCT | TT low | — | — | TT low |
| ACTN3 | CT moderate | CC low | CC low | — |
| ALDH2 | — | GG low | GG low | — |
| CYP1A2 | — | AC moderate | AA moderate | AA moderate |
| FTO | AT elevated | AT elevated | AT low | — |
| VDR | CT moderate | — | CT moderate | CT moderate |
| COMT | AG moderate | — | AG moderate | AA low |
| HFE | — | AG elevated | — | GG low |
Elevated/high risk: Adithya
Arya ← Priya · Adithya ← Kumar
Elevated/high risk: Priya, Kumar, Adithya, Arya
Arya ← Priya
Elevated/high risk: Kumar, Arya
Adithya ← Kumar · Arya ← Kumar
Elevated/high risk: Kumar
Connect 23andMe for more family members to complete the inheritance picture: